Tygacil, like other tetracyclines, may cause enamel loss and staining in developing teeth. Xerava is contraindicated for use in patients with known hypersensitivity to eravacycline, tetracyclineclass antibacterial drugs, or to any of the excipients. Tigecycline marketed as tygacil prescribing and label information. After reconstitution, 1 ml contains 10 mg of tigecycline. Tygacil 50mg powder for solution for infusion summary of. Interactions between tygacil intravenous and tetracyclines. Find patient medical information for tygacil intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Tygacil tigecycline dose, indications, adverse effects. Physician prescribing information see related articles. To report any serious adverse events associated with the use of this drug, please contact the fda medwatch. Tygacil 50 mg injection is an antibiotic which is used to treat infections in the abdomen, skin, and lungs.
Vabomere meropenem and vaborbactam for injection, for intravenous use initial u. Each 5 ml tygacil vial contains 50 mg of tigecycline. Our purpose is to investigate tgc safety and efficacy at higher. Tygacil tigecycline for injection for intravenous use initial u. Tigecycline is an antibiotic for a number of bacterial infections. Webmd provides information about interactions between tygacil intravenous and tetracyclinesselectedretinoidssystemic. Highlights of prescribing information these highlights do not include all the information needed to use vabomere safely and effectively. Initially 100 mg, followed by 50 mg 12 hrly 514 days. The recommended dosage regimen for tygacil is an initial dose of 100 mg, followed by 50 mg every 12 hours. The high incidence of multidrugresistant mdr bacteria among patients admitted to icus has determined an increase of tigecycline tgc use for the treatment of severe infections. Call your doctor for medical advice about side effects.
Consumer medicine information cmi about tygacil tigecycline intended for persons living in australia. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Tygacil tigecycline this product information is intended only for residents of the united states. Dos avycaz ceftazidime and avibactam for injection, for intravenous use initial u. Tygacil tigecycline dosage and administration pfizer medical. See 17for patient counseling information and fdaapproved patient labeling. To reduce the development of drugresistant bacteria and maintain the effectiveness of tygacil and other antibacterial drugs, tygacil. Tygacil tigecycline for injection for intravenous use. Evaluation of tigecycline efficacy and postdischarge. The utility of tigecycline as compared with other antibiotic therapies in the treatment of patients with complicated intraabdominal infection ciai and the short and longterm outcomes of a large cohort of severely ill patients were examined. Tygacil tigecycline is an injectable antibiotic used to treat severe infections. An adverse drug reaction adr was any untoward medical occurrence attributed to tygacil in a participant who received tygacil. Tigecycline for the treatment of patients with severe sepsis.
Know tygacil 50 mg injection uses, side effects, dosage, contraindications. Many concerns have been raised about the efficacy of this molecule and. High dose tigecycline in critically ill patients with. Side effects of tygacil tigecycline, warnings, uses. Stefanie swoboda, michael ober, christian hainer, christoph lichtenstern, christoph seiler, constanze wendt, torsten hoppetichy, markus buchler, markus a. Weigand, tigecycline for the treatment of patients with severe sepsis or septic shock. Tygacil is given as an intravenous infusion, usually in hospital. New commercial products and drug formularies for 2014.
Tygacil package insert chlortetracycline, the first, was discovered in 1948. Tigecycline is used to treat many different bacterial infections of the skin or the digestive system. See full prescribing information for complete boxed warning. Cipro xr ciprofloxacin extendedrelease tablets, for oral use initial u.
Our tygacil tigecycline side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Tygacil tigecycline highlights pfizer medical information. Product monograph download pdf, 483kb patient information download pdf, 185kb canadian regulations limit the scope of information we are permitted to give on prescription drugs via the internet or other means. Highlights of prescribing information age group dosage. Tygacil was discontinued due to adverse reactions in 7% of patients compared to 6% for all comparators.
Tigecycline for injection is indicated in patients 18 years of age and older for the treatment of complicated skin and skin structure infections caused by susceptible isolates of escherichia coli. What should i avoid while using tigecycline tygacil. Tigecycline for the treatment of patients with severe. This medicine is not used regularly unless necessary. Tygacil is a tetracycline class antibiotic in the glycylcycline subcategory and may have similar adverse effects. To assess the efficacy and safety of tygacil in the usual german hospital setting.
Tigecycline 50 mg powder for solution for infusion. A new boxed warning has been added to tygacil prescribing information describing an increased risk of death when it is. Review trial description, criteria and location information here. Allcause mortality was higher in patients treated with tygacil than comparators in a metaanalysis of clinical trials. May 05, 2014 the high incidence of multidrugresistant mdr bacteria among patients admitted to icus has determined an increase of tigecycline tgc use for the treatment of severe infections. Tygacil tigecycline adverse reactions pfizer medical. It was developed in response to the growing rate of antibiotic resistant bacteria such as staphylococcus aureus, acinetobacter baumannii, and e. Tygacil should bereserved foruse in situations when. No specific information is available on the treatment of overdosage. As a tetracycline derivative antibiotic, its structural modifications has. Tygacil tigecycline for injection, for intravenous use initial u. Highlights of prescribing information these highlights do not include all the information needed to use avycaz safely and effectively.
A pharmacovigilance evaluation and assessment of the prescribing practice for tygacil in usual health care setting. Jan 01, 2020 tigecycline official prescribing information for healthcare professionals. It may increase the risk of sunburns when exposed to the sunlight. See full prescribing information for fluzone highdose. Tygacil is a tetracyclineclass antibacterial indicated for the treatment of infections caused by susceptible isolates of the designated microorganisms in the conditions listed below for patients 18 years of age and older. Highlights of prescribing information see full prescribing. Highlights of prescribing information these highlights do not include all the information needed to use alimta safely and effectively.
Prescribing information pdf open prescribing information. Feb 03, 2020 what should i avoid while using tigecycline tygacil. Read the patient information leaflet if available from your pharmacist before you start using tigecycline and each time you get a refill. Pristiq is not approved for use in pediatric patients. If you develop another bacterial infection, your doctor may prescribe a different antibiotic. Tygacil tigecycline for injection, for intravenous use. As a tetracycline derivative antibiotic, its structural modifications has expanded its. Tygacil is indicated in adults and in children from the age of eight years for the treatment of the. Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors. Tigecycline fda prescribing information, side effects and uses. If you would like to see the patient information leaflet pil or summary of product characteristics spc for tygacil these can be found at the electronic medicines compendium emc.
High dose tigecycline in critically ill patients with severe. Tygacil may be administered intravenously through a dedicated line through a y site. The following serious adverse reactions are described elsewhere in the labeling. This page contains prescription brand name drugs that are trademarks or registered trademarks. Highlights of prescribing information these highlights do not include all the information needed to use cubicin safely and effectively. It is a first in class glycylcycline that is administered intravenously. Click to view detailed tygacil indicationsuses dosage direction for use adult initially 100 mg, followed by 50 mg 12 every hr by iv infusion over approx 3060 min every 12 hr. Table 1 shows the incidence of adverse reactions through test of cure reported in. Download leaflet view the patient leaflet in pdf format.
Allcause mortality see full prescribing information for complete. This document contains confidential and proprietary information of molina healthcare and cannot be reproduced, distributed or printed without written permission from molina healthcare. If the same intravenous line is used for sequential infusion of several drugs, the line should be flushed before and after infusion of tygacil with 0. Childn 1217 yr 50 mg iv infusion every 12 hr, 811 yr 1. Please consult a qualified health professional for more detailed information.
Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Apr 15, 2019 each 5 ml tygacil vial contains 50 mg of tigecycline. Powder for solution for infusion powder for infusion. Tygacil is an antibiotic of the glycylcycline group that works by stopping the growth of bacteria that. Prescribing tigecycline in the absence of a proven or strongly suspected. Canadian regulations limit the scope of information we are permitted to give on prescription drugs via the internet or other means. Tygacil fda prescribing information, side effects and uses. Intravenous infusions of tygacil should be administered over approximately 30 to 60 minutes every 12 hours. Australian product information tygacil tigecycline. Alimta pemetrexedfor injection, for intravenous use initial u. Pfizer is currently recruiting for the nct00488488 infection cancer trial.
If the same intravenous line is used for sequential infusion of several drugs, the line should be flushed before and after infusion of tigecycline with either 0. Information for the user tygacil 50 mg powder for solution for infusion tigecycline read all of this leaflet carefully before you are given this medicine because it contains important information for you or your child. We provide the first published data on postdischarge events for these patients. If you have any further questions, ask your doctor or nurse. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Food and drug administration fda notified healthcare professionals of a finding of increased allcause mortality across phase 3 and 4 clinical trials in tigecyclinetreated patients versus comparators. Pharmacy department, university hospital of heidelberg. Know tygacil 50 mg injection uses, side effects, dosage, contraindications, substitutes, benefit. Tygacil will not work against viral infections such as colds or flu. Severe hepatic impairment 100 mg, then 25 mg 12 hrly. Tigecycline for the treatment of patients with severe sepsis or septic shock. Our purpose is to investigate tgc safety and efficacy at higher than standard doses.
Click to view detailed tygacil dosagedirection for use. Tygacil may be administered intravenously through a dedicated line or through a ysite. Tygacil tigecycline side effects, images, uses, dosage. This is not a complete list of side effects and others may occur. This information is generalized and not intended as specific medical advice. This medicine may cause teeth discoloration in the children. Please contact pfizer canada medical information at 1 800 4636001 with any comments or inquiries. Highlights of prescribing information infancy, and childhood. See full prescribing information for complete boxed warning renal dysfunction, acute renal failure, osmotic nephropathy, and death may occur with immune globulin intravenous igiv products in. Tygacil 50 mg injection uses, dosage, side effects. Since then, multiple additional tetracyclines have been isolated or derived. Fluzone highdose influenza vaccine suspension for intramuscular injection. Highlights of prescribing information these highlights do not include all the information needed to use gammagard liquid safely and effectively.
Highlights of prescribing information infancy, and. Adult initially 100 mg, followed by 50 mg 12 every hr by iv infusion over approx 3060 min every 12 hr. If you encounter technical difficulties in viewing our product. Prescribing tygacil in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and increases the risk of the development of drugresistant bacteria. Prescribing tigecycline in the absence of a proven or strongly suspected bacterial infection is. Highlights of prescribing information these highlights do not include all the information needed to use tygacil safely and effectively. Tygacil tigecycline dosage and administration pfizer. Jan 29, 2020 see full prescribing information for complete boxed warning. Increased the risk of suicidal thoughts and behaviors in children, adolescents and young adults taking antidepressants. Tigecycline is an antibiotic that fights bacteria in the body.